Organic electrochemical transistors as novel biosensing platforms to study the electrical response of whole blood and plasma

Valentina Preziosi; Mario Barra; Giovanna Tomaiuolo; Pasquale D’Angelo; Simone Luigi Marasso; Alessio Verna; Matteo Cocuzza; Antonio Cassinese; Stefano Guido

doi:10.1039/D1TB01584B

Organic electrochemical transistors as novel biosensing platforms to study the electrical response of whole blood and plasma†

Valentina Preziosi,

*^a Mario Barra,

*^b Giovanna Tomaiuolo,^a Pasquale D’Angelo,

^c Simone Luigi Marasso,

^cd Alessio Verna,^d Matteo Cocuzza,^cd Antonio Cassinese^be and Stefano Guido

^afg

Author affiliations

* Corresponding authors

^a Department of Chemical, Materials and Production Engineering - University Federico II, P.le Tecchio 80, I-80125 Naples, Italy
E-mail: valentina.preziosi@unina.it

^b CNR-SPIN, c/o Department of Physics “Ettore Pancini”, P.le Tecchio, 80, I-80125 Napoli, Italy
E-mail: mario.barra@spin.cnr.it

^c IMEM-CNR, Parco Area delle Scienze 37/A, I-43124 Parma, Italy

^d Chi-Lab, Department of Applied Science and Technology, Politecnico di Torino, C.so Duca degli Abruzzi 24, 10129 Torino, Italy

^e Department of Physics “Ettore Pancini”, University Federico II, P.le Tecchio 80, I-80125 Naples, Italy

^f National Interuniversity Consortium for Materials Science and Technology (INSTM), 50121 Firenze, Italy

^g CEINGE, Advanced Biotechnologies, 80145 Napoli, Italy

Abstract

In this paper, for the first time to the best of our knowledge, organic electrochemical transistors are employed to investigate the electrical response of human blood, plasma and alternative buffer solutions that inhibit red blood cell (RBC) aggregation. Our focus is on selecting a suitable electrolytic platform and the related operating conditions, where the RBC effect on the OECT response can be observed separately from the strong ionic environment of plasma in whole blood. The transient response of whole blood to pulse experiments is characterized by two time constants, which can be related to blood viscosity and to the capacitive coupling between the ionic and electronic components of the overall system. The role of capacitive effects, likely due to enhanced double-layer formation by negatively charged RBCs, is also confirmed by the increase of transconductance which was found in RBC suspensions as compared to the suspending buffer. Overall, the complex behavior found in these experiments provides new insights for the development of innovative blood-based sensing devices for biomedical applications.

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DOI: https://doi.org/10.1039/D1TB01584B
Article type: Paper
Submitted: 19 Jul 2021
Accepted: 20 Nov 2021
First published: 22 Nov 2021

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J. Mater. Chem. B, 2022,10, 87-95

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Organic electrochemical transistors as novel biosensing platforms to study the electrical response of whole blood and plasma

V. Preziosi, M. Barra, G. Tomaiuolo, P. D’Angelo, S. L. Marasso, A. Verna, M. Cocuzza, A. Cassinese and S. Guido, J. Mater. Chem. B, 2022, 10, 87 DOI: 10.1039/D1TB01584B

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Journal of Materials Chemistry B

Organic electrochemical transistors as novel biosensing platforms to study the electrical response of whole blood and plasma†

Abstract

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Organic electrochemical transistors as novel biosensing platforms to study the electrical response of whole blood and plasma

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