Issue 10, 2022
From the journal:

Chemical Science

Emerging biosensing and transducing techniques for potential applications in point-of-care diagnostics

Junjie Qin, ORCID logo *a   Wei Wang,ab   Liqian Gao ORCID logo b  and  Shao Q. Yao ORCID logo *a  

* Corresponding authors

a Department of Chemistry, National University of Singapore, 4 Science Drive 2, Singapore 117544
E-mail: chmqj@nus.edu.sg, chmyaosq@nus.edu.sg

b School of Pharmaceutical Sciences, Sun Yat-sen University, Shenzhen, P. R. China

Abstract

With the deepening of our understanding in life science, molecular biology, nanotechnology, optics, electrochemistry and other areas, an increasing number of biosensor design strategies have emerged in recent years, capable of providing potential practical applications for point-of-care (POC) diagnosis in various human diseases. Compared to conventional biosensors, the latest POC biosensor research aims at improving sensor precision, cost-effectiveness and time-consumption, as well as the development of versatile detection strategies to achieve multiplexed analyte detection in a single device and enable rapid diagnosis and high-throughput screening. In this review, various intriguing strategies in the recognition and transduction of POC (from 2018 to 2021) are described in light of recent advances in CRISPR technology, electrochemical biosensing, and optical- or spectra-based biosensing. From the perspective of promoting emerging bioanalytical tools into practical POC detecting and diagnostic applications, we have summarized key advances made in this field in recent years and presented our own perspectives on future POC development and challenges.

Graphical abstract: Emerging biosensing and transducing techniques for potential applications in point-of-care diagnostics

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Article information

DOI
https://doi.org/10.1039/D1SC06269G
Article type
Review Article
Submitted
11 Nov 2021
Accepted
11 Jan 2022
First published
11 Jan 2022
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2022,13, 2857-2876

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Emerging biosensing and transducing techniques for potential applications in point-of-care diagnostics

J. Qin, W. Wang, L. Gao and S. Q. Yao, Chem. Sci., 2022, 13, 2857 DOI: 10.1039/D1SC06269G

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