Issue 15, 2021

Cobalt-catalyzed carbonylative cycloaddition of substituted diynes to access complexed polycyclic compounds

Abstract

A cobalt-catalyzed domino Pauson–Khand and [4 + 2] cycloaddition of substituted diynes has been developed for the rapid construction of complexed polycyclic ring systems. Using benzene-1,3,5-triyl triformate (TFBen) as the CO source, the reaction proceeded well to give various tetracyclic compounds bearing two new quaternary carbon cores in high yields with excellent regioselectivity and diastereoselectivity. Control experiments were performed to gain a better understanding of the reaction mechanism.

Graphical abstract: Cobalt-catalyzed carbonylative cycloaddition of substituted diynes to access complexed polycyclic compounds

Supplementary files

Article information

Article type
Research Article
Submitted
10 May 2021
Accepted
02 Jun 2021
First published
03 Jun 2021

Org. Chem. Front., 2021,8, 4188-4191

Cobalt-catalyzed carbonylative cycloaddition of substituted diynes to access complexed polycyclic compounds

J. Wang, Q. Wang, Y. Zhu, Q. Gao, J. Ying and X. Wu, Org. Chem. Front., 2021, 8, 4188 DOI: 10.1039/D1QO00725D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements