Two mixed valence diruthenium(II,III) isomeric complexes show different anticancer properties

Elisabetta Barresi; Iogann Tolbatov; Tiziano Marzo; Elisa Zappelli; Alessandro Marrone; Nazzareno Re; Alessandro Pratesi; Claudia Martini; Sabrina Taliani; Federico Da Settimo; Diego La Mendola

doi:10.1039/D1DT01492G

Two mixed valence diruthenium(ii,iii) isomeric complexes show different anticancer properties†

Elisabetta Barresi,

‡^ac Iogann Tolbatov,

‡^b Tiziano Marzo,

*^ac Elisa Zappelli,^a Alessandro Marrone,

^d Nazzareno Re,*^d Alessandro Pratesi,

^e Claudia Martini,^ac Sabrina Taliani,*^ac Federico Da Settimo^ac and Diego La Mendola^a

Author affiliations

* Corresponding authors

^a Department of Pharmacy, University of Pisa, Via Bonanno Pisano, 6, Pisa, Italy
E-mail: tiziano.marzo@unipi.it, sabrina.taliani@unipi.it

^b Institut de Chimie Moleculaire de l'Université de Bourgogne (ICMUB), Université de Bourgogne Franche-Comté (UBFC), avenue Alain Savary 9, Dijon, France

^c CISUP-Centro per l'Integrazione della Strumentazione Scientifica dell'Università di Pisa, University of Pisa, Italy

^d Dipartimento di Farmacia, Università degli Studi “G. D'Annunzio” Chieti-Pescara, Via dei Vestini, I-66100 Chieti, Italy
E-mail: nre@unich.it

^e Department of Chemistry and Industrial Chemistry, University of Pisa, Via G. Moruzzi, 13, 56124 Pisa, Italy

Abstract

In this paper it is demonstrated that the nature of the ligands of two Ru₂(II,III) paddlewheel complexes dramatically affects the overall anticancer properties in cells. Herein, the complex [Ru₂(EB776)₄Cl] was found to be more active against a glioblastoma model with respect to its isomer [Ru₂(EB106)₄Cl]. These different effects depend on the steric hindrance, on the allowed conformations of the complexes and on the presence of hydrophilic regions in [Ru₂(EB776)₄Cl], which overall lead to a lower “steric protection”.

Dalton Transactions

Two mixed valence diruthenium(ii,iii) isomeric complexes show different anticancer properties†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Two mixed valence diruthenium(II,III) isomeric complexes show different anticancer properties

Social activity

Search articles by author

Spotlight

Advertisements