Issue 7, 2022
From the journal:

Chemical Communications

Enantioselective formal [2 + 2 + 2] cycloaddition of 1,3,5-triazinanes to construct tetrahydropyrimidin-4-one derivatives†

Peiran Ruan,a   Qiong Tang,a   Zun Yang,a   Xiaohua Liu ORCID logo *a  and  Xiaoming Feng ORCID logo *a  

* Corresponding authors

a Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China
E-mail: liuxh@scu.edu.cn, xmfeng@scu.edu.cn

Abstract

A chiral Lewis acid-catalyzed enantioselective formal [2 + 2 + 2] cycloaddition of 1,3,5-triazinanes with azlactones or β,γ-unsaturated pyrazole amides was developed to synthesize chiral tertiary/quaternary tetrahydropyrimidin-4-one derivatives with good yields and enantioselectivities. Two competitive reaction pathways were proposed based on experiments.

Graphical abstract: Enantioselective formal [2 + 2 + 2] cycloaddition of 1,3,5-triazinanes to construct tetrahydropyrimidin-4-one derivatives

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D1CC06549A
Article type
Communication
Submitted
22 Nov 2021
Accepted
08 Dec 2021
First published
09 Dec 2021

Chem. Commun., 2022,58, 1001-1004

Permissions

Request permissions

Enantioselective formal [2 + 2 + 2] cycloaddition of 1,3,5-triazinanes to construct tetrahydropyrimidin-4-one derivatives

P. Ruan, Q. Tang, Z. Yang, X. Liu and X. Feng, Chem. Commun., 2022, 58, 1001 DOI: 10.1039/D1CC06549A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements