Issue 27, 2020
From the journal:

RSC Advances

Enabling protein-hosted organocatalytic transformations

Alexander R. Nödling, ORCID logo a   Nicolò Santi, ORCID logo a   Thomas L. Williams,a   Yu-Hsuan Tsai ORCID logo a  and  Louis Y. P. Luk ORCID logo *a  

* Corresponding authors

a School of Chemistry, Cardiff University, Main Building, Cardiff, UK
E-mail: lukly@cardiff.ac.uk

Abstract

In this review, the development of organocatalytic artificial enzymes will be discussed. This area of protein engineering research has underlying importance, as it enhances the biocompatibility of organocatalysis for applications in chemical and synthetic biology research whilst expanding the catalytic repertoire of enzymes. The approaches towards the preparation of organocatalytic artificial enzymes, techniques used to improve their performance (selectivity and reactivity) as well as examples of their applications are presented. Challenges and opportunities are also discussed.

Graphical abstract: Enabling protein-hosted organocatalytic transformations

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Article information

DOI
https://doi.org/10.1039/D0RA01526A
Article type
Review Article
Submitted
17 Feb 2020
Accepted
25 Mar 2020
First published
23 Apr 2020
This article is Open Access
Creative Commons BY license

RSC Adv., 2020,10, 16147-16161

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Enabling protein-hosted organocatalytic transformations

A. R. Nödling, N. Santi, T. L. Williams, Y. Tsai and L. Y. P. Luk, RSC Adv., 2020, 10, 16147 DOI: 10.1039/D0RA01526A

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