Issue 64, 2020, Issue in Progress
From the journal:

RSC Advances

Ionic magnetic core–shell nanoparticles for DNA extraction†

Tammar Hussein Ali, ORCID logo ab   Amar Mousa Mandal,c   Thorsten Heidelberg, ORCID logo *a   Rusnah Syahila Duali Hussena  and  Ean Wai Goha  

* Corresponding authors

a Chemistry Department, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
E-mail: heidelberg@um.edu.my

b Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Muthanna University, 66001 Samawah, Al Muthanna, Iraq
E-mail: tammar86@gmail.com, tammar@mu.edu.iq

c College of Basic Education, Science Department, Al-Muthanna University, 66001 Samawah, Al Muthanna, Iraq

Abstract

Magnetic nanoparticles with specific surface features are interesting materials for biomedical applications. The combination of molecular interactions on small particles with macroscopic cohesion forces offers unique opportunities. This work reports the synthesis of magnetic core–shell nanoparticles with alkylimidazolium coated surface for effective DNA extraction. A magnetic Fe2O3 core was coated with a silica shell and functionalized with an organic halide. This enabled a surface coating with organic cations to mediate effective molecular interactions with polyanionic DNA. The large surface area of the ∼20 nm small particles with a magnetization of 25 emu g−1 enabled high DNA particle loading of 1/30 m% with easy isolation based on an external magnetic field. Moreover, the coating of the particles stabilized DNA against ultrasound initiated fragmentation.

Graphical abstract: Ionic magnetic core–shell nanoparticles for DNA extraction

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Article information

DOI
https://doi.org/10.1039/D0RA05933A
Article type
Paper
Submitted
07 Jul 2020
Accepted
16 Oct 2020
First published
23 Oct 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 38818-38830

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Ionic magnetic core–shell nanoparticles for DNA extraction

T. H. Ali, A. M. Mandal, T. Heidelberg, R. S. Duali Hussen and E. W. Goh, RSC Adv., 2020, 10, 38818 DOI: 10.1039/D0RA05933A

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