Automated access to well-defined ionic oligosaccharides

Yuntao Zhu; Theodore Tyrikos-Ergas; Kevin Schiefelbein; Andrea Grafmüller; Peter H. Seeberger; Martina Delbianco

doi:10.1039/D0OB00137F

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Automated access to well-defined ionic oligosaccharides†

Yuntao Zhu,

^a Theodore Tyrikos-Ergas,

^ab Kevin Schiefelbein,^a Andrea Grafmüller,

^c Peter H. Seeberger

^ab and Martina Delbianco

*^a

Author affiliations

* Corresponding authors

^a Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam, Germany
E-mail: martina.delbianco@mpikg.mpg.de

^b Department of Chemistry and Biochemistry, Freie Universität Berlin, Arnimallee 22, 14195 Berlin, Germany

^c Department of Theory, Max-Planck-Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam, Germany

Abstract

Ionic polysaccharides are part of many biological events, but lack structural characterisation due to challenging purifications and complex synthesis. Four monosaccharides bearing modifications not found in nature are used for the automated synthesis of a collection of ionic oligosaccharides. Structural analysis reveals how the charge pattern affects glycan conformation.

This article is part of the themed collections: Chemical Biology in OBC and Glycosylation: New methodologies and applications

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Article information

DOI: https://doi.org/10.1039/D0OB00137F
Article type: Communication
Submitted: 21 Jan 2020
Accepted: 04 Feb 2020
First published: 04 Feb 2020
This article is Open Access

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Org. Biomol. Chem., 2020,18, 1349-1353

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Automated access to well-defined ionic oligosaccharides

Y. Zhu, T. Tyrikos-Ergas, K. Schiefelbein, A. Grafmüller, P. H. Seeberger and M. Delbianco, Org. Biomol. Chem., 2020, 18, 1349 DOI: 10.1039/D0OB00137F

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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Organic & Biomolecular Chemistry

Automated access to well-defined ionic oligosaccharides†

Abstract

Supplementary files

Article information

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Automated access to well-defined ionic oligosaccharides

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