Reversible hydrogen-bonded polymerization regulated by allosteric metal templation

Tangxin Xiao; Weiwei Zhong; Weiwei Yang; Lijie Qi; Yan Gao; Andrew C.-H. Sue; Zheng-Yi Li; Xiao-Qiang Sun; Chen Lin; Leyong Wang

doi:10.1039/D0CC06381A

Reversible hydrogen-bonded polymerization regulated by allosteric metal templation†

Tangxin Xiao,

*^a Weiwei Zhong,^a Weiwei Yang,^b Lijie Qi,^a Yan Gao,^b Andrew C.-H. Sue,

^bc Zheng-Yi Li,

^a Xiao-Qiang Sun,^a Chen Lin^ad and Leyong Wang

^ad

Author affiliations

* Corresponding authors

^a Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, School of Petrochemical Engineering, Changzhou University, Changzhou, China
E-mail: xiaotangxin@cczu.edu.cn

^b Institute for Molecular Design and Synthesis, School of Pharmaceutical Science & Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin 300072, China

^c College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, P. R. China

^d School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China

Abstract

Allosteric effects are common in biology, but have not been fully explored in the control of supramolecular polymerization. Herein, ditopic UPy derivatives with acyclic crown ether-like spacers were designed and synthesized, which can undergo supramolecular polymerization through quadruple hydrogen bonding. Upon the addition of K⁺, drastic molecular conformational change to the U-shape is induced by metal-coordination, reconfiguring remote UPy sites towards the formation of discrete cyclic dimers. Interestingly, the supramolecular polymerization can be restored by simply removing K⁺ by water-extraction.

Chemical Communications

Reversible hydrogen-bonded polymerization regulated by allosteric metal templation†

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