Issue 14, 2020

Viscoelasticity of hydrazone crosslinked poly(ethylene glycol) hydrogels directs chondrocyte morphology during mechanical deformation

Abstract

Chondrocyte deformation influences disease progression and tissue regeneration in load-bearing joints. In this work, we found that viscoelasticity of dynamic covalent crosslinks temporally modulates the biophysical transmission of physiologically relevant compressive strains to encapsulated chondrocytes. Chondrocytes in viscoelastic alky-hydrazone hydrogels demonstrated (91.4 ± 4.5%) recovery of native rounded morphologies during mechanical deformation, whereas primarily elastic benzyl-hydrazone hydrogels significantly limited morphological recovery (21.2 ± 1.4%).

Graphical abstract: Viscoelasticity of hydrazone crosslinked poly(ethylene glycol) hydrogels directs chondrocyte morphology during mechanical deformation

Supplementary files

Article information

Article type
Communication
Submitted
22 May 2020
Accepted
19 Jun 2020
First published
23 Jun 2020

Biomater. Sci., 2020,8, 3804-3811

Viscoelasticity of hydrazone crosslinked poly(ethylene glycol) hydrogels directs chondrocyte morphology during mechanical deformation

B. M. Richardson, C. J. Walker, L. J. Macdougall, J. W. Hoye, M. A. Randolph, S. J. Bryant and K. S. Anseth, Biomater. Sci., 2020, 8, 3804 DOI: 10.1039/D0BM00860E

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