Issue 8, 2021
From the journal:

Biomaterials Science

Amphiphilic polymer therapeutics: an alternative platform in the fight against antibiotic resistant bacteria

Haruko Takahashi, ORCID logo *a   Gregory A. Caputo ORCID logo b  and  Kenichi Kuroda ORCID logo c  

* Corresponding authors

a Graduate School of Integrated Sciences for Life, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-8526, Japan
E-mail: harukot@hiroshima-u.ac.jp

b Department of Chemistry & Biochemistry, Rowan University, 201 Mullica Hill Rd, Glassboro, NJ 08028, USA

c Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI 48109, USA

Abstract

As we are on the cusp of the “post-antibiotic” era due to rapid spread of drug resistant bacteria, there is an urgent need for new antimicrobials that are not susceptible to bacterial resistance mechanisms. In this review, we will discuss the recent development of “polymer therapeutics” with antimicrobial activity. Learning from host-defence peptides, we propose the biomimetic design of synthetic polymers to target bacterial cell membranes, which act by compromising the membrane integrity. The discussion is extended to the future challenges and opportunities of antimicrobial polymers for clinical applications.

Graphical abstract: Amphiphilic polymer therapeutics: an alternative platform in the fight against antibiotic resistant bacteria

About
Cited by
Related
Download options Please wait...

Article information

DOI
https://doi.org/10.1039/D0BM01865A
Article type
Review Article
Submitted
02 Nov 2020
Accepted
16 Jan 2021
First published
27 Jan 2021

Biomater. Sci., 2021,9, 2758-2767

Author version available


Download author version (PDF)

Permissions

Request permissions

Amphiphilic polymer therapeutics: an alternative platform in the fight against antibiotic resistant bacteria

H. Takahashi, G. A. Caputo and K. Kuroda, Biomater. Sci., 2021, 9, 2758 DOI: 10.1039/D0BM01865A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements