Issue 23, 2019
From the journal:

RSC Advances

Rapid and halide compatible synthesis of 2-N-substituted indazolone derivatives via photochemical cyclization in aqueous media†

Hui-Jun Nie,ab   An-Di Guo,b   Hai-Xia Lina  and  Xiao-Hua Chen ORCID logo *b  

* Corresponding authors

a Department of Chemistry, Innovative Drug Research Center, College of Sciences Shanghai University, Shanghai, China

b Chinese Academy of Sciences Key Laboratory of Receptor Research, Synthetic Organic & Medicinal Chemistry Laboratory, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
E-mail: xhchen@simm.ac.cn

Abstract

Indazolone derivatives exhibit a wide range of biological and pharmaceutical properties. We report a rapid and efficient approach to provide structurally diverse 2-N-substituted indazolones via photochemical cyclization in aqueous media at room temperature. This straightforward protocol is halide compatible for the synthesis of halogenated indazolones bearing a broad scope of substrates, which suggests a new avenue of great importance to medicinal chemistry.

Graphical abstract: Rapid and halide compatible synthesis of 2-N-substituted indazolone derivatives via photochemical cyclization in aqueous media

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Article information

DOI
https://doi.org/10.1039/C9RA02466B
Article type
Paper
Submitted
01 Apr 2019
Accepted
19 Apr 2019
First published
30 Apr 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 13249-13253

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Rapid and halide compatible synthesis of 2-N-substituted indazolone derivatives via photochemical cyclization in aqueous media

H. Nie, A. Guo, H. Lin and X. Chen, RSC Adv., 2019, 9, 13249 DOI: 10.1039/C9RA02466B

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