Issue 57, 2019
From the journal:

RSC Advances

Microfluidic synthesis of PLGA/carbon quantum dot microspheres for vascular endothelial growth factor delivery

Meisam Omidi, ORCID logo a   Mohadeseh Hashemibc  and  Lobat Tayebi ORCID logo *a  

* Corresponding authors

a Marquette University School of Dentistry, Milwaukee, WI, USA
E-mail: Lobat.tayebi@marquette.edu

b Department of Biomedical Engineering, The University of Texas at Austin, Austin, USA

c Division of Pharmaceutics, College of Pharmacy, The University of Texas at Austin, Austin, USA

Abstract

In this study, vascular endothelial growth factor (VEGF) loaded poly(D,L-lactide-co-glycolide) (PLGA) – carbon quantum dot microspheres were produced using microfluidic platforms. The microcapsules were fabricated in flow-focusing geometry with a biphasic flow to generate solid/oil/water (s–o–w) droplets. To avoid any damage to protein functional and structural stability during the encapsulation process, the VEGF was PEGylated. The produced microspheres were intact and highly monodisperse in size (CV < 5%). Furthermore, microspheres in a size range of 16–36 µm were achieved by adjusting the flow ratio parameter. The encapsulation efficiency, release profile, and bioactivity of the produced microparticles were also studied. The loading efficiency of PEGylated VEGF in the microparticles was varied from 51–69% and more than 90% of PEGylated VEGF was released within 28 days. Furthermore, the release of VEGF was indirectly monitored by carbon quantum dots. The present monodisperse and controllable VEGF loaded microspheres with reproducible manner could be widely used in tissue engineering and therapeutic applications.

Graphical abstract: Microfluidic synthesis of PLGA/carbon quantum dot microspheres for vascular endothelial growth factor delivery

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Article information

DOI
https://doi.org/10.1039/C9RA06279C
Article type
Paper
Submitted
12 Aug 2019
Accepted
08 Oct 2019
First published
17 Oct 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 33246-33256

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Microfluidic synthesis of PLGA/carbon quantum dot microspheres for vascular endothelial growth factor delivery

M. Omidi, M. Hashemi and L. Tayebi, RSC Adv., 2019, 9, 33246 DOI: 10.1039/C9RA06279C

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