SCHEDULED MAINTENANCE
Synthesis of meta-substituted anilines via a three-component reaction of acetone, amines, and 1,3-diketones†
Andrew R.
Galeev, 
a
Maksim V.
Dmitriev,
*a
Ivan G.
Mokrushin,
a
Andrey N.
Maslivets
a
and
Michael
Rubin
*bc
a
Maksim V.
Dmitriev,
*a
Ivan G.
Mokrushin,
a
Andrey N.
Maslivets
a
and
Michael
Rubin
*bc
Abstract
A facile method for the synthesis of meta-substituted arylamines from acyclic precursors was developed. This method is based on three-component cyclo-condensation/aromatization of in situ generated imines of acetone with 1,3-diketones either under conventional heating or under microwave irradiation. The utility of this methodology is illustrated by the possibility of a gram scale synthesis of various anilines from readily available reagents.
- This article is part of the themed collection: Synthetic methodology in OBC
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