Comparative study of core- and surface-radiolabeling strategies for the assembly of iron oxide nanoparticle-based theranostic nanocomposites

Junzhe Zhang; Yuhui Ma; Wenjiang Yang; Jingquan Xue; Yayun Ding; Changjian Xie; Wenhe Luo; Fuping Gao; Zhiyong Zhang; Yuliang Zhao; Zhifang Chai; Xiao He

doi:10.1039/C9NR00428A

Comparative study of core- and surface-radiolabeling strategies for the assembly of iron oxide nanoparticle-based theranostic nanocomposites†

Junzhe Zhang,

^ab Yuhui Ma,

^a Wenjiang Yang,^a Jingquan Xue,^a Yayun Ding,^a Changjian Xie,^ab Wenhe Luo,^ab Fuping Gao,^a Zhiyong Zhang,^ab Yuliang Zhao,

^a Zhifang Chai^a and Xiao He

*^a

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* Corresponding authors

^a CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China
E-mail: hexiao@ihep.ac.cn

^b School of Physical Sciences, University of the Chinese Academy of Sciences, Beijing 100049, China

Abstract

This work highlights the superiority of the surface-radiolabeling strategy over the core-labeling strategy in the assembly of radioactive iron oxide nanoparticle (IONP)-based nanocomposites for use in multimodal imaging and targeted therapy. It also implies a possible overestimation of the labeling stability in previous studies and points out directions for further optimization.

Nanoscale

Comparative study of core- and surface-radiolabeling strategies for the assembly of iron oxide nanoparticle-based theranostic nanocomposites†

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Comparative study of core- and surface-radiolabeling strategies for the assembly of iron oxide nanoparticle-based theranostic nanocomposites

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