Issue 36, 2019
From the journal:

Nanoscale

Transdermal delivery of small interfering RNAs with topically applied mesoporous silica nanoparticles for facile skin cancer treatment†

Daniel Chin Shiuan Lio,‡abc   Chenghao Liu,‡c   Myo Myo Swe Oo,a   Christian Wiraja,a   Melissa Hui Yen Teo,d   Mengjia Zheng,a   Sharon Wan Ting Chew,ab   Xiaomeng Wangcdef  and  Chenjie Xu ORCID logo *abg  

* Corresponding authors

a School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore

b NTU Institute for Health Technologies, Interdisciplinary Graduate School, Nanyang Technological University, 50 Nanyang Drive, Singapore

c Lee Kong Chian School of Medicine, Nanyang Technological University, 59 Nanyang Drive, Singapore, Singapore

d Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Proteos, 61 Biopolis Dr, Singapore, Singapore

e Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower Level 6, Singapore

f Institute of Ophthalmology, University College London, 11-43 Bath Street, London, UK

g National Dental Centre of Singapore, 5 Second Hospital Ave, Singapore

Abstract

Small interfering RNA (siRNA) is a promising tool for the treatment of skin disorders including skin squamous cell carcinoma (SCC). This article develops a topical formulation for the transdermal delivery of siRNA. The formulation is built on mesoporous silica nanoparticles (MSNPs) with a loading capacity of 1.4 μg of oligonucleotide per mg of MSNPs. Cell experiments are employed to study the functionality of the formulation including the cellular uptake, the qualitative and quantitative detection of specific gene biomarkers. The clinical potential of this system is examined by topically delivering siRNA targeting TGFβR-1 (TGFβR-1) to the SCC in a mouse xenograft model. In comparison to the controls, MSNPs containing TGFβR-1 siRNA show a 2-fold suppression of TGFβR-1.

Graphical abstract: Transdermal delivery of small interfering RNAs with topically applied mesoporous silica nanoparticles for facile skin cancer treatment

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Article information

DOI
https://doi.org/10.1039/C9NR06303J
Article type
Paper
Submitted
24 Jul 2019
Accepted
02 Sep 2019
First published
03 Sep 2019

Nanoscale, 2019,11, 17041-17051

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Transdermal delivery of small interfering RNAs with topically applied mesoporous silica nanoparticles for facile skin cancer treatment

D. C. S. Lio, C. Liu, M. M. S. Oo, C. Wiraja, M. H. Y. Teo, M. Zheng, S. W. T. Chew, X. Wang and C. Xu, Nanoscale, 2019, 11, 17041 DOI: 10.1039/C9NR06303J

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