Zero valent iron core–iron oxide shell nanoparticles as small magnetic particle imaging tracers

Lucy Gloag; Milad Mehdipour; Marina Ulanova; Kevin Mariandry; Muhammad Azrhy Nichol; Daniela J. Hernández-Castillo; Jeff Gaudet; Ruirui Qiao; Ji Zhang; Melanie Nelson; Benjamin Thierry; Mayra A. Alvarez-Lemus; Thiam T. Tan; J. Justin Gooding; Nady Braidy; Perminder S. Sachdev; Richard D. Tilley

doi:10.1039/C9CC08972A

Zero valent iron core–iron oxide shell nanoparticles as small magnetic particle imaging tracers†

Lucy Gloag,

*^a Milad Mehdipour,^a Marina Ulanova,^b Kevin Mariandry,^a Muhammad Azrhy Nichol,^a Daniela J. Hernández-Castillo,

^c Jeff Gaudet,^d Ruirui Qiao,

^e Ji Zhang,^a Melanie Nelson,

^e Benjamin Thierry,

^f Mayra A. Alvarez-Lemus,

^c Thiam T. Tan,^a J. Justin Gooding,

^agh Nady Braidy,

^b Perminder S. Sachdev

^bi and Richard D. Tilley

*^ajk

Author affiliations

* Corresponding authors

^a School of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia
E-mail: l.gloag@unsw.edu.au, r.tilley@unsw.edu.au

^b Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, NSW 2052, Australia

^c Laboratorio de Nanotecnología, Centro de Investigación de Ciencia y Tecnología Avanzada de Tabasco (CICTAT-UJAT), Cunduacán, Tabasco, Mexico

^d Magnetic Insight, Inc., 1010 Atlantic Avenue, Suite 100, Alameda, CA 94501, USA

^e Ferronova Pty Ltd, Salisbury South, SA 5106, Australia

^f Ian Wark Research Institute, University of South Australia, Mawson Lakes Campus, SA 5095, Australia

^g ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, VIC 3052, Australia

^h Australian Centre for NanoMedicine, University of New South Wales Sydney, NSW 2052, Australia

ⁱ Neuropsychiatric Institute, Prince of Wales Hospital, Randwick, NSW 2031, Australia

^j ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, The University of New South Wales Sydney, NSW 2052, Australia

^k Electron Microscope Unit, Mark Wainwright Analytical Centre, University of New South Wales Sydney, NSW 2052, Australia

Abstract

Nanoparticle tracers with small sizes and large magnetization are critical for biomedical imaging and especially for magnetic particle imaging (MPI). Small size is important for accessing future intracellular and neurological in vivo applications Here, we show <15 nm nanoparticles made of zero valent iron cores, iron oxide shells and coated with a strongly binding brush co-polymer are effective MPI tracers. The small nanoparticle cores create a hydrodynamic diameter that is half of the state-of-the-art iron oxide tracers while the strongly magnetic zero valent iron maintains similar MPI signal magnitude and resolution.

Chemical Communications

Zero valent iron core–iron oxide shell nanoparticles as small magnetic particle imaging tracers†

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Zero valent iron core–iron oxide shell nanoparticles as small magnetic particle imaging tracers

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