Issue 50, 2019
From the journal:

Chemical Communications

Parahydrogen induced hyperpolarization provides a tool for NMR metabolomics at nanomolar concentrations†

Lisanne Sellies,a   Indrek Reile, ORCID logo b   Ruud L. E. G. Aspers,a   Martin C. Feiters, ORCID logo a   Floris P. J. T. Rutjes ORCID logo a  and  Marco Tessari ORCID logo *a  

* Corresponding authors

a Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands
E-mail: m.tessari@science.ru.nl

b National Institute of Chemical Physics and Biophysics, Akadeemia tee 23, 12618 Tallinn, Estonia

Abstract

An NMR approach based on parahydrogen hyperpolarization is presented to detect and resolve specific classes of metabolites in complex biomixtures at down to nanomolar concentrations. We demonstrate our method on solid phase extracts of urine, by simultaneously observing hundreds of metabolites well below the limits of detection of thermal NMR.

Graphical abstract: Parahydrogen induced hyperpolarization provides a tool for NMR metabolomics at nanomolar concentrations

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Article information

DOI
https://doi.org/10.1039/C9CC02186H
Article type
Communication
Submitted
10 Apr 2019
Accepted
30 May 2019
First published
30 May 2019

Chem. Commun., 2019,55, 7235-7238

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Parahydrogen induced hyperpolarization provides a tool for NMR metabolomics at nanomolar concentrations

L. Sellies, I. Reile, R. L. E. G. Aspers, M. C. Feiters, F. P. J. T. Rutjes and M. Tessari, Chem. Commun., 2019, 55, 7235 DOI: 10.1039/C9CC02186H

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