Issue 31, 2019

Development of a mitochondria-targeted fluorescent probe for the ratiometric visualization of sulfur dioxide in living cells and zebrafish

Abstract

Herein, a mitochondria-targeted ratiometric fluorescent probe for SO2 was proposed based on the FRET coumarin–phenylchromenylium dyad. The probe showed two distinct emission bands centered at 485 and 650 nm. Upon exposure to SO2, the acceptor emission was inhibited, and a significant enhancement in donor fluorescence was simultaneously induced; this resulted in a satisfactory ratiometric fluorescence signal. Importantly, the probe was biocompatible and successfully applied to monitor SO2 in live HeLa cells and zebrafish.

Graphical abstract: Development of a mitochondria-targeted fluorescent probe for the ratiometric visualization of sulfur dioxide in living cells and zebrafish

Supplementary files

Article information

Article type
Communication
Submitted
09 Jun 2019
Accepted
09 Jul 2019
First published
11 Jul 2019

Anal. Methods, 2019,11, 3931-3935

Development of a mitochondria-targeted fluorescent probe for the ratiometric visualization of sulfur dioxide in living cells and zebrafish

Y. Yang, L. He, K. Xu and W. Lin, Anal. Methods, 2019, 11, 3931 DOI: 10.1039/C9AY01211G

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