Issue 9, 2019
From the journal:

RSC Advances

Designing photolabile ruthenium polypyridyl crosslinkers for hydrogel formation and multiplexed, visible-light degradation†

Teresa L. Rapp,a   Yanfei Wang,b   Maegan A. Delessio,a   Michael R. Gaua  and  Ivan J. Dmochowski ORCID logo *a  

* Corresponding authors

a Department of Chemistry, University of Pennsylvania, 231 S 34th St., Philadelphia, PA, USA
E-mail: ivandmo@sas.upenn.edu

b Department of Anesthesiology, Division of Critical Care Medicine Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA, USA

Abstract

Photoresponsive materials afford spatiotemporal control over desirable physical, chemical and biological properties. For advanced applications, there is need for molecular phototriggers that are readily incorporated within larger structures, and spatially-sequentially addressable with different wavelengths of visible light, enabling multiplexing. Here we describe spectrally tunable (λmax = 420–530 nm) ruthenium polypyridyl complexes functionalized with two photolabile nitrile ligands that present terminal alkynes for subsequent crosslinking reactions, including hydrogel formation. Two Ru crosslinkers were incorporated within a PEG–hydrogel matrix, and sequentially degraded by irradiation with 592 nm and 410 nm light.

Graphical abstract: Designing photolabile ruthenium polypyridyl crosslinkers for hydrogel formation and multiplexed, visible-light degradation

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Article information

DOI
https://doi.org/10.1039/C8RA09764J
Article type
Paper
Submitted
27 Nov 2018
Accepted
26 Jan 2019
First published
08 Feb 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 4942-4947

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Designing photolabile ruthenium polypyridyl crosslinkers for hydrogel formation and multiplexed, visible-light degradation

T. L. Rapp, Y. Wang, M. A. Delessio, M. R. Gau and I. J. Dmochowski, RSC Adv., 2019, 9, 4942 DOI: 10.1039/C8RA09764J

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