Issue 38, 2018
From the journal:

RSC Advances

Core/shell upconversion nanoparticles with intense fluorescence for detecting doxorubicin in vivo

Junshan Hu,†a   Shiping Zhan,†a   Xiaofeng Wu,*b   Shigang Hu,b   Shaobing Wua  and  Yunxin Liu ORCID logo *a  

* Corresponding authors

a Department of Physics and Electronic Science, China

b Department of Information Science, Hunan University of Science and Technology, Xiangtan 411201, China
E-mail: lyunxin@163.com

Abstract

Doxorubicin (Dox) is a chemotherapy medication used to treat cancer. Herein, we report a rapid and efficient method for detecting Dox in vivo based on a NaGdF4:Yb3+,Er3+@NaYF4 core/shell upconversion nanoparticles (UCNPs) probe. We found that the intensity ratio of green to red emission (IGVRE) bands of the core/shell NaGdF4:Yb3+,Er3+@NaYF4 nanoparticles was sensitive to Dox in blood samples, and drops as the concentration of Dox increases. In addition, the proposed UCNPs probe possessed the advantage that no nanoparticles leaked into the living body, thus overcoming the intrinsic defect (difficulty in removing UCNPs from blood vessels) of the fluorescence resonance energy transfer (FRET) approach. This proposed UCNP probe design and results may provide some guidance for the real-time and efficient detection of Dox, and can be helpful in biomedical applications.

Graphical abstract: Core/shell upconversion nanoparticles with intense fluorescence for detecting doxorubicin in vivo

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Article information

DOI
https://doi.org/10.1039/C8RA02928H
Article type
Paper
Submitted
05 Apr 2018
Accepted
17 May 2018
First published
12 Jun 2018
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2018,8, 21505-21512

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Core/shell upconversion nanoparticles with intense fluorescence for detecting doxorubicin in vivo

J. Hu, S. Zhan, X. Wu, S. Hu, S. Wu and Y. Liu, RSC Adv., 2018, 8, 21505 DOI: 10.1039/C8RA02928H

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