Issue 11, 2018
From the journal:

Organic Chemistry Frontiers

A Rh(iii)-catalyzed redox-neutral C–H alkylation reaction with allylic alcohols by using a traceless oxidizing directing group†

Yubo Wang,ab   Yu Chen,*a   Yaxi Yangb  and  Bing Zhou ORCID logo *b  

* Corresponding authors

a College of Chemistry and Materials Science, South-Central University for Nationalities, Wuhan 430074, PR China
E-mail: chenyuwh888@126.com

b State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, PR China
E-mail: zhoubing@simm.ac.cn, zhoubing2012@hotmail.com

Abstract

By using a traceless oxidizing directing group, a Rh(III)-catalyzed C–H alkylation of N-phenoxyacetamides with allylic alcohols has been developed under mild and redox-neutral conditions. This transformation provided an efficient methodology for the synthesis of valuable β-aryl ketones in good to excellent yields.

Graphical abstract: A Rh(iii)-catalyzed redox-neutral C–H alkylation reaction with allylic alcohols by using a traceless oxidizing directing group

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Article information

DOI
https://doi.org/10.1039/C8QO00265G
Article type
Research Article
Submitted
11 Mar 2018
Accepted
20 Apr 2018
First published
25 Apr 2018

Org. Chem. Front., 2018,5, 1844-1847

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A Rh(III)-catalyzed redox-neutral C–H alkylation reaction with allylic alcohols by using a traceless oxidizing directing group

Y. Wang, Y. Chen, Y. Yang and B. Zhou, Org. Chem. Front., 2018, 5, 1844 DOI: 10.1039/C8QO00265G

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