Efficient assembly of ynones via palladium-catalyzed sequential carbonylation/alkynylation

Miao Hu; Yang Gao; Wanqing Wu; Jianxiao Li; Chunsheng Li; Hao Zhang; Huanfeng Jiang

doi:10.1039/C8OB02092B

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Efficient assembly of ynones via palladium-catalyzed sequential carbonylation/alkynylation†

Miao Hu,^a Yang Gao,^a Wanqing Wu,

^a Jianxiao Li,^a Chunsheng Li,^a Hao Zhang^a and Huanfeng Jiang

*^a

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* Corresponding authors

^a Key Laboratory of Functional Molecular Engineering of Guangdong Province, Guangdong Engineering Research Center for Green Fine Chemicals, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, P. R. China
E-mail: jianghf@scut.edu.cn

Abstract

Based on the intramolecular Heck-type reaction, a convenient and efficient strategy to construct functionalized ynones by a palladium-catalyzed cascade annulation reaction has been developed. This reaction possesses good functional group compatibility, a broad substrate scope, and high atom- and step-economy. Furthermore, this approach could also be extended to direct alkynylation that gave another route to synthesize dihydrobenzofurans.

This article is part of the themed collection: Synthetic methodology in OBC

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Article information

DOI: https://doi.org/10.1039/C8OB02092B
Article type: Paper
Submitted: 27 Aug 2018
Accepted: 18 Sep 2018
First published: 19 Sep 2018

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Org. Biomol. Chem., 2018,16, 7383-7392

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Efficient assembly of ynones via palladium-catalyzed sequential carbonylation/alkynylation

M. Hu, Y. Gao, W. Wu, J. Li, C. Li, H. Zhang and H. Jiang, Org. Biomol. Chem., 2018, 16, 7383 DOI: 10.1039/C8OB02092B

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Organic & Biomolecular Chemistry

Efficient assembly of ynones via palladium-catalyzed sequential carbonylation/alkynylation†

Abstract

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Efficient assembly of ynones via palladium-catalyzed sequential carbonylation/alkynylation

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