Dynamically crosslinked polymer nanocomposites to treat multidrug-resistant bacterial biofilms

Dong Yu Zhu; Ryan F. Landis; Cheng-Hsuan Li; Akash Gupta; Li-Sheng Wang; Yingying Geng; Sanjana Gopalakrishnan; Jian Wei Guo; Vincent M. Rotello

doi:10.1039/C8NR06348F

Dynamically crosslinked polymer nanocomposites to treat multidrug-resistant bacterial biofilms†

Dong Yu Zhu,‡^ab Ryan F. Landis,‡^b Cheng-Hsuan Li,^b Akash Gupta,^b Li-Sheng Wang,^b Yingying Geng,^b Sanjana Gopalakrishnan,^b Jian Wei Guo*^a and Vincent M. Rotello

*^b

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* Corresponding authors

^a School of Chemical Engineering and Light Industry, Guangdong University of Technology, 100 Wai Huan Xi Road, Guangzhou, Guangdong, China

^b Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts, USA
E-mail: rotello@chem.umass.edu, guojw@gdut.edu.cn

Abstract

Multidrug-resistant biofilms are highly resistant to current antimicrobial therapies. We have developed an antimicrobial platform that integrates the bacteria-killing phytochemical carvacrol into dynamically crosslinked polymer nanocomposites (DCPNs). Taking advantage of a reversibly crosslinked Schiff-base scaffold throughout the engineered emulsions, DCPNs exhibited long-term shelf-life and good stability in serum, while readily disassembling in acidic microenvironments. Furthermore, we demonstrated that DCPNs efficiently penetrate the biofilm matrix, eradicating both Gram-negative/positive bacteria enclosed within. Moreover, DCPNs showed no observable toxicity to fibroblast mammalian cells with the same antimicrobial concentrations necessary to eradicate MDR biofilms. Given their potent antimicrobial and stimuli-responsive dissociation characteristics in a biofilm setting, DCPNs are a suitable therapeutic platform for combating MDR bacterial infections.

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DOI: https://doi.org/10.1039/C8NR06348F
Article type: Paper
Submitted: 06 Aug 2018
Accepted: 04 Sep 2018
First published: 05 Sep 2018

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Nanoscale, 2018,10, 18651-18656

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Dynamically crosslinked polymer nanocomposites to treat multidrug-resistant bacterial biofilms

D. Y. Zhu, R. F. Landis, C. Li, A. Gupta, L. Wang, Y. Geng, S. Gopalakrishnan, J. W. Guo and V. M. Rotello, Nanoscale, 2018, 10, 18651 DOI: 10.1039/C8NR06348F

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Dynamically crosslinked polymer nanocomposites to treat multidrug-resistant bacterial biofilms†

Abstract

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Dynamically crosslinked polymer nanocomposites to treat multidrug-resistant bacterial biofilms

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