Copper-mediated intramolecular aminofluorination of 1,3-dienes by using nucleophilic fluorine reagents

Zuxiao Zhang; Pinhong Chen; Guosheng Liu

doi:10.1039/C8CC04909B

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Copper-mediated intramolecular aminofluorination of 1,3-dienes by using nucleophilic fluorine reagents†

Zuxiao Zhang,^a Pinhong Chen*^a and Guosheng Liu

*^a

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* Corresponding authors

^a State Key Laboratory of Organometallic Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, China
E-mail: pinhongchen@sioc.ac.cn, gliu@mail.sioc.ac.cn

Abstract

A copper-mediated intramolecular aminofluorination of 1,3-dienes is disclosed, in which both AgF and Et₃N·3HF can be used as the fluorine source. This protocol provides a variety of pyrrolidines bearing allylic fluorides with excellent regioselectivities and good diastereoselectivities.

This article is part of the themed collection: Fluorine Chemistry

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Article information

DOI: https://doi.org/10.1039/C8CC04909B
Article type: Communication
Submitted: 20 Jun 2018
Accepted: 11 Jul 2018
First published: 11 Jul 2018

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Chem. Commun., 2018,54, 8709-8712

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Copper-mediated intramolecular aminofluorination of 1,3-dienes by using nucleophilic fluorine reagents

Z. Zhang, P. Chen and G. Liu, Chem. Commun., 2018, 54, 8709 DOI: 10.1039/C8CC04909B

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Chemical Communications

Copper-mediated intramolecular aminofluorination of 1,3-dienes by using nucleophilic fluorine reagents†

Abstract

Supplementary files

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Copper-mediated intramolecular aminofluorination of 1,3-dienes by using nucleophilic fluorine reagents

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