Recent development on the [5+2] cycloadditions and their application in natural product synthesis

Kai Gao; Yong-Gang Zhang; Zhiming Wang; Hanfeng Ding

doi:10.1039/C8CC09077G

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Recent development on the [5+2] cycloadditions and their application in natural product synthesis

Kai Gao,

^a Yong-Gang Zhang,^a Zhiming Wang

^a and Hanfeng Ding

*^ab

Author affiliations

* Corresponding authors

^a Institute of Medicinal Natural Products, School of Advanced Study, Taizhou University, Taizhou 318000, P. R. China
E-mail: hfding@zju.edu.cn

^b Department of Chemistry, Zhejiang University, Hangzhou 310058, P. R. China

Abstract

The [5+2] cycloaddition is one kind of fascinating and powerful reaction to access seven-membered ring systems existing in complex natural products and pharmaceuticals. In this review, recent developments on the [5+2] cycloadditions and their application in the synthesis of complex natural products are discussed. A focus is given to the way in which the [5+2] cycloadditions have influenced the logical process of the synthesis. This article is organized by reaction types, aiming to provide a clear clue to the latest research trends.

This article is part of the themed collection: Natural product synthesis

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Article information

DOI: https://doi.org/10.1039/C8CC09077G
Article type: Feature Article
Submitted: 15 Nov 2018
Accepted: 15 Jan 2019
First published: 16 Jan 2019

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Chem. Commun., 2019,55, 1859-1878

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Recent development on the [5+2] cycloadditions and their application in natural product synthesis

K. Gao, Y. Zhang, Z. Wang and H. Ding, Chem. Commun., 2019, 55, 1859 DOI: 10.1039/C8CC09077G

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Chemical Communications

Recent development on the [5+2] cycloadditions and their application in natural product synthesis

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Recent development on the [5+2] cycloadditions and their application in natural product synthesis

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