Issue 66, 2018
From the journal:

Chemical Communications

A near-infrared heptamethine aminocyanine dye with a long-lived excited triplet state for photodynamic therapy†

Long Jiao,a   Fengling Song, ORCID logo *a   Jingnan Cuia  and  Xiaojun Peng ORCID logo a  

* Corresponding authors

a State Key Laboratory of Fine Chemicals, Dalian University of Technology, No. 2 Linggong Road, High-tech District, Dalian, China
E-mail: songfl@dlut.edu.cn

Abstract

A water-soluble near-infrared aminocyanine dye has been developed with a long triplet-state lifetime (τ = 9.16 μs in deaerated ethanol). Thereby, extremely high singlet oxygen quantum yield (ΦΔ = 0.20) and low dark cytotoxicity (IC50 = 715.4 μM) were achieved. The potential of the dye as a PDT photosensitizer was demonstrated.

Graphical abstract: A near-infrared heptamethine aminocyanine dye with a long-lived excited triplet state for photodynamic therapy

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Article information

DOI
https://doi.org/10.1039/C8CC04582H
Article type
Communication
Submitted
08 Jun 2018
Accepted
24 Jul 2018
First published
25 Jul 2018

Chem. Commun., 2018,54, 9198-9201

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A near-infrared heptamethine aminocyanine dye with a long-lived excited triplet state for photodynamic therapy

L. Jiao, F. Song, J. Cui and X. Peng, Chem. Commun., 2018, 54, 9198 DOI: 10.1039/C8CC04582H

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