Gold nanoshell coated thermo-pH dual responsive liposomes for resveratrol delivery and chemo-photothermal synergistic cancer therapy

Meili Wang; Yanping Liu; Xuwu Zhang; Liyao Luo; Lei Li; Shanshan Xing; Yuchu He; Weiwei Cao; Ruiyan Zhu; Dawei Gao

doi:10.1039/C7TB00258K

Gold nanoshell coated thermo-pH dual responsive liposomes for resveratrol delivery and chemo-photothermal synergistic cancer therapy†

Meili Wang,^ab Yanping Liu,^a Xuwu Zhang,^a Liyao Luo,^a Lei Li,^a Shanshan Xing,^ab Yuchu He,^a Weiwei Cao,^a Ruiyan Zhu^a and Dawei Gao

*^ab

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* Corresponding authors

^a Applying Chemistry Key Lab of Hebei Province, Yanshan University, No. 438 Hebei Street, Qinhuangdao, China
E-mail: dwgao@ysu.edu.cn
Fax: +86 335 8387553
Tel: +86 335 8387553

^b Hebei Province Asparagus Industry Technology Research Institute, Qinhuangdao, China

Abstract

Stimuli-responsive drug delivery and release have a great significance in cancer therapy. Herein, a multifunctional responsive drug carrier was designed and developed by loading resveratrol (Res) in chitosan (CTS) modified liposomes, and coated by gold nanoshells (GNS@CTS@Res-lips). The resultant GNS@CTS@Res-lips possess broad near-infrared (NIR) absorbance, high capability, stability, and also high photothermal conversion ability for efficient photothermal therapy (PTT) applications. In addition, the GNS@CTS@Res-lips exhibit the on-demand pH/photothermal-sensitive drug release, and a high loading capacity of Res. Under NIR laser irradiation, the drug delivery system could significantly enhance the cellular uptake of drugs. More importantly, compared to the single chemotherapy or PTT, the carriers with NIR irradiation displayed a higher therapeutic effect for HeLa cells. Therefore, the GNS@CTS@Res-lips with a combination of chemotherapy and PTT will show great potential for application in cancer therapy.

Journal of Materials Chemistry B

Gold nanoshell coated thermo-pH dual responsive liposomes for resveratrol delivery and chemo-photothermal synergistic cancer therapy†

Abstract

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Gold nanoshell coated thermo-pH dual responsive liposomes for resveratrol delivery and chemo-photothermal synergistic cancer therapy

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