Grandiflodines A and B, two novel diterpenoid alkaloids from Delphinium grandiflorum

Neng-Hua Chen; Yu-Bo Zhang; Wen Li; Pan Li; Li-Feng Chen; Yao-Lan Li; Guo-Qiang Li; Guo-Cai Wang

doi:10.1039/C7RA02869E

Grandiflodines A and B, two novel diterpenoid alkaloids from Delphinium grandiflorum†

Neng-Hua Chen,^ab Yu-Bo Zhang,^ab Wen Li,^ab Pan Li,^ab Li-Feng Chen,^ab Yao-Lan Li,^ab Guo-Qiang Li*^c and Guo-Cai Wang*^ab

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* Corresponding authors

^a Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, P. R. China
E-mail: twangguocai@jnu.edu.cn

^b Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, P. R. China

^c Foshan University, Foshan, P. R. China
E-mail: liguoqiang@jnu.edu.cn

Abstract

Two novel diterpenoid alkaloids, grandiflodines A and B (1 and 2), were isolated from Delphinium grandiflorum. Compound 1 represents a rare hetisine-type C₂₀-diterpenoid alkaloid in which the bond between the atoms of N and C-17 is broken. Compound 2 features an unusual lycoctonine-type C₁₉-diterpenoid alkaloid skeleton with the cleavage of N–C₁₉ and C₇–C₁₇ bonds, and the construction of the N–C₇ bond. Structural elucidations of the isolates were performed by spectroscopic analysis, X-ray diffraction and comparison with the literature. These compounds were tested for their antiviral and anti-inflammatory activities.

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DOI: https://doi.org/10.1039/C7RA02869E
Article type: Paper
Submitted: 09 Mar 2017
Accepted: 26 Apr 2017
First published: 03 May 2017
This article is Open Access

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RSC Adv., 2017,7, 24129-24132

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Grandiflodines A and B, two novel diterpenoid alkaloids from Delphinium grandiflorum

N. Chen, Y. Zhang, W. Li, P. Li, L. Chen, Y. Li, G. Li and G. Wang, RSC Adv., 2017, 7, 24129 DOI: 10.1039/C7RA02869E

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Grandiflodines A and B, two novel diterpenoid alkaloids from Delphinium grandiflorum†

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Grandiflodines A and B, two novel diterpenoid alkaloids from Delphinium grandiflorum

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