Issue 10, 2017

Phosphinodifluoroalkylation of alkynes using P(O)H compounds and ethyl difluoroiodoacetate

Abstract

The first phosphinodifluoroalkylation of alkynes is achieved and the simultaneous addition of both difluoromethylene and phosphinoyl groups across the alkynes with high regio- and stereoselectivity is of great significance. By using palladium(II) chloride as a catalyst and Xantphos as a ligand, the reaction of P(O)H compounds, alkynes, and ethyl difluoroiodoacetate proceeds with moderate to high yields, and provides an attractive approach for the construction of (E)-γ,γ-difluoroalkenylphosphine oxides.

Graphical abstract: Phosphinodifluoroalkylation of alkynes using P(O)H compounds and ethyl difluoroiodoacetate

Supplementary files

Article information

Article type
Research Article
Submitted
13 Jun 2017
Accepted
14 Jul 2017
First published
17 Jul 2017

Org. Chem. Front., 2017,4, 2054-2057

Phosphinodifluoroalkylation of alkynes using P(O)H compounds and ethyl difluoroiodoacetate

P. Zhang, J. Ying, G. Tang and Y. Zhao, Org. Chem. Front., 2017, 4, 2054 DOI: 10.1039/C7QO00466D

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