A reactive oxygen species-generating, cyclooxygenase-2 inhibiting, cancer stem cell-potent tetranuclear copper(II) cluster

C. Lu; K. Laws; A. Eskandari; K. Suntharalingam

doi:10.1039/C7DT02789C

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A reactive oxygen species-generating, cyclooxygenase-2 inhibiting, cancer stem cell-potent tetranuclear copper(ii) cluster†

C. Lu,^ab K. Laws,

^a A. Eskandari^a and K. Suntharalingam

*^a

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* Corresponding authors

^a Department of Chemistry, King's College London, London, UK
E-mail: kogularamanan.suntharalingam@kcl.ac.uk

^b College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001, China

Abstract

Tetranuclear copper(II) complexes containing multiple diclofenac and Schiff base moieties, 1–4, are shown to kill bulk cancer cells and cancer stem cells (CSCs) with low micromolar potency. The most effective complex, 1, elicits its cytotoxic effect by elevating the intracellular reactive oxygen species (ROS) levels and inhibiting cyclooxygenase-2 (COX-2) expression.

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Article information

DOI: https://doi.org/10.1039/C7DT02789C
Article type: Communication
Submitted: 30 Jul 2017
Accepted: 03 Sep 2017
First published: 04 Sep 2017

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Dalton Trans., 2017,46, 12785-12789

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A reactive oxygen species-generating, cyclooxygenase-2 inhibiting, cancer stem cell-potent tetranuclear copper(II) cluster

C. Lu, K. Laws, A. Eskandari and K. Suntharalingam, Dalton Trans., 2017, 46, 12785 DOI: 10.1039/C7DT02789C

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Dalton Transactions

A reactive oxygen species-generating, cyclooxygenase-2 inhibiting, cancer stem cell-potent tetranuclear copper(ii) cluster†

Abstract

Supplementary files

Article information

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A reactive oxygen species-generating, cyclooxygenase-2 inhibiting, cancer stem cell-potent tetranuclear copper(II) cluster

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