Issue 10, 2018
From the journal:

Chemical Communications

Expanding the chemical diversity of TNA with tUTP derivatives that are substrates for a TNA polymerase†

Hui Mei ORCID logo a  and  John C. Chaput ORCID logo *a  

* Corresponding authors

a Departments of Pharmaceutical Sciences, Chemistry, Molecular Biology and Biochemistry, University of California, Irvine, CA 92697-3958, USA
E-mail: jchaput@uci.edu

Abstract

Expanding the chemical diversity of threose nucleic acid (TNA) beyond the natural bases would enable the development of TNA polymers with enhanced physicochemical properties. Here, we describe a versatile approach for increasing the chemical diversity of TNA using 5-alkynyl-modified α-L-threofuranosyl uridine triphosphates that are substrates for a TNA polymerase.

Graphical abstract: Expanding the chemical diversity of TNA with tUTP derivatives that are substrates for a TNA polymerase

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Article information

DOI
https://doi.org/10.1039/C7CC09130C
Article type
Communication
Submitted
27 Nov 2017
Accepted
10 Jan 2018
First published
17 Jan 2018

Chem. Commun., 2018,54, 1237-1240

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Expanding the chemical diversity of TNA with tUTP derivatives that are substrates for a TNA polymerase

H. Mei and J. C. Chaput, Chem. Commun., 2018, 54, 1237 DOI: 10.1039/C7CC09130C

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