Issue 54, 2017
From the journal:

Chemical Communications

Practical in situ-generation of phosphinite ligands for palladium-catalyzed carbonylation of (hetero)aryl bromides forming esters†

Lin Wang,a   Helfried Neumann,a   Anke Spannenberga  and  Matthias Beller ORCID logo *a  

* Corresponding authors

a Leibniz-Institut für Katalyse an der Universität Rostock, Albert-Einstein-Straße 29a, 18059 Rostock, Germany
E-mail: matthias.beller@catalysis.de

Abstract

An effective method for alkoxycarbonylation of (hetero)aryl bromides is developed in the presence of in situ-generated phosphinite ligands tBu2POR (R = nBu, nPr, Et or Me). For this purpose commercially available tBu2PCl was used as the pre-ligand in the presence of different alcohols. For the first time cross coupling reactions with two alcohols – one generating the ligand, the other used as substrate – were developed. Through this method, ligand optimization can be performed in a more efficient manner and the desired products could be obtained with good yields and selectivity.

Graphical abstract: Practical in situ-generation of phosphinite ligands for palladium-catalyzed carbonylation of (hetero)aryl bromides forming esters

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Article information

DOI
https://doi.org/10.1039/C7CC02828H
Article type
Communication
Submitted
12 Apr 2017
Accepted
09 Jun 2017
First published
12 Jun 2017

Chem. Commun., 2017,53, 7469-7472

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Practical in situ-generation of phosphinite ligands for palladium-catalyzed carbonylation of (hetero)aryl bromides forming esters

L. Wang, H. Neumann, A. Spannenberg and M. Beller, Chem. Commun., 2017, 53, 7469 DOI: 10.1039/C7CC02828H

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