Issue 94, 2016, Issue in Progress
From the journal:

RSC Advances

Transition metal-free synthesis of α-ketoamides from arylmethyl ketones and alkylphosphoramides†

Ahalya Behera,a   Wajid Ali,a   Manisha Tripathy,a   Diptimayee Sahooa  and  Bhisma K. Patel*a  

* Corresponding authors

a Department of Chemistry, Indian Institute of Technology Guwahati, Assam, India
E-mail: patel@iitg.ernet.in
Fax: +91-3612690762

Abstract

A transition metal-free protocol has been developed for the synthesis of α-ketoamides from aryl methyl ketones and alkylphosphoramides in the presence of oxidant, aqueous tert-butyl hydroperoxide (TBHP). A series of aryl methyl ketones having both electron-donating as well as electron-withdrawing groups were successfully employed for the synthesis of their corresponding α-ketoamides using hexamethylphosphoramide and other alkylphosphoramides.

Graphical abstract: Transition metal-free synthesis of α-ketoamides from arylmethyl ketones and alkylphosphoramides

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Article information

DOI
https://doi.org/10.1039/C6RA16118A
Article type
Communication
Submitted
21 Jun 2016
Accepted
18 Aug 2016
First published
19 Aug 2016

RSC Adv., 2016,6, 91308-91313

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Transition metal-free synthesis of α-ketoamides from arylmethyl ketones and alkylphosphoramides

A. Behera, W. Ali, M. Tripathy, D. Sahoo and B. K. Patel, RSC Adv., 2016, 6, 91308 DOI: 10.1039/C6RA16118A

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