Issue 11, 2016
From the journal:

Organic & Biomolecular Chemistry

Synthesis of triazole-linked morpholino oligonucleotides via CuI catalysed cycloaddition†

Matthew J. Palframan,‡a   Rima D. Alharthy,§‡a   Paulina K. Powalowskaa  and  Christopher J. Hayes*a  

* Corresponding authors

a School of Chemistry, University of Nottingham, University Park, Nottingham, UK
E-mail: chris.hayes@nottingham.ac.uk
Tel: +44 (0)115 951 3045

Abstract

Triazole-linked morpholino (TLMO) oligonucleic acids were synthesised using the CuI catalysed (3 + 2) azide–alkyne cycloaddition (CuAAC) reaction. The modified DNA analogues were incorporated into 13-mer sequences via solid phase synthesis. UV melting experiments showed that the TLMO modification gives higher Tm values than the corresponding TLDNA modification.

Graphical abstract: Synthesis of triazole-linked morpholino oligonucleotides via CuI catalysed cycloaddition

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Article information

DOI
https://doi.org/10.1039/C6OB00007J
Article type
Paper
Submitted
04 Jan 2016
Accepted
16 Feb 2016
First published
16 Feb 2016
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2016,14, 3112-3119

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Synthesis of triazole-linked morpholino oligonucleotides via CuI catalysed cycloaddition

M. J. Palframan, R. D. Alharthy, P. K. Powalowska and C. J. Hayes, Org. Biomol. Chem., 2016, 14, 3112 DOI: 10.1039/C6OB00007J

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