Robust surface coating for a fast, facile fluorine-18 labeling of iron oxide nanoparticles for PET/MR dual-modality imaging

Ziyan Sun; Kai Cheng; Fengyu Wu; Hongguang Liu; Xiaowei Ma; Xinhui Su; Yang Liu; Liming Xia; Zhen Cheng

doi:10.1039/C6NR07298D

Robust surface coating for a fast, facile fluorine-18 labeling of iron oxide nanoparticles for PET/MR dual-modality imaging†

Ziyan Sun,‡^ab Kai Cheng,‡^b Fengyu Wu,^bc Hongguang Liu,^b Xiaowei Ma,^b Xinhui Su,^b Yang Liu,^b Liming Xia*^a and Zhen Cheng*^b

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* Corresponding authors

^a Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China
E-mail: lmxia@tjh.tjmu.edu.cn

^b Molecular Imaging Program at Stanford (MIPS), Bio-X Program, Department of Radiology, Stanford University, California, USA
E-mail: zcheng@stanford.edu

^c Department of Nuclear Medicine, PET/CT Center, Affiliated Hospital of Qingdao University, Qingdao, China

Abstract

Grafting a robust organic shell around inorganic nanoparticles can optimize their colloidal features to dramatically improve their physicochemical properties. Here, we have developed a polymer coating procedure for providing colloidal stability to the nanoparticles and, more importantly, for applying a fast, facile fluorine-18 labeling of iron oxide nanoparticles (IONPs) for positron emission tomography (PET)/magnetic resonance (MR) dual-modality imaging. The structure of the amphiphilic polymer is based on a backbone of polyacrylic acid, conjugated with multiple oleylamines to form a comb-like branched structure. The dense polymer shell provides high colloidal stability to the IONPs against harsh conditions such as high temperature, low pH value, and high ion strength. By incorporating a 1,4,7-triazacyclononane (NOTA) chelator to the comb-like amphiphilic polymer for the chelation of aluminum fluoride ions, we applied a one-step radiolabeling approach for a fast, facile radiofluorination of magnetic nanoparticles. The new strategy can significantly reduce the procedure time and radiation exposure. The PET/MR dual modality imaging was successfully achieved in living subjects by using ¹⁸F labeled magnetic nanoparticles.

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DOI: https://doi.org/10.1039/C6NR07298D
Article type: Paper
Submitted: 15 Sep 2016
Accepted: 28 Oct 2016
First published: 31 Oct 2016
This article is Open Access

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Nanoscale, 2016,8, 19644-19653

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Robust surface coating for a fast, facile fluorine-18 labeling of iron oxide nanoparticles for PET/MR dual-modality imaging

Z. Sun, K. Cheng, F. Wu, H. Liu, X. Ma, X. Su, Y. Liu, L. Xia and Z. Cheng, Nanoscale, 2016, 8, 19644 DOI: 10.1039/C6NR07298D

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Nanoscale

Robust surface coating for a fast, facile fluorine-18 labeling of iron oxide nanoparticles for PET/MR dual-modality imaging†

Abstract

Supplementary files

Article information

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Robust surface coating for a fast, facile fluorine-18 labeling of iron oxide nanoparticles for PET/MR dual-modality imaging

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