Issue 23, 2016
From the journal:

Nanoscale

Externally controlled drug release using a gold nanorod contained composite membrane†

Kibeom Kim,‡ab   Min-Chul Jo,‡a   Sundo Jeong,a   L. Palanikumar,b   Vincent M. Rotello,c   Ja-Hyoung Ryu*b  and  Myoung-Hwan Park*a  

* Corresponding authors

a Department of Chemistry, Sahmyook University, Seoul, Korea
E-mail: mpark@syu.ac.kr

b Department of Chemistry, Ulsan National Institute of Science and Technology, Ulsan, Korea
E-mail: jhryu@unist.ac.kr

c Department of Chemistry, University of Massachusetts, Amherst, MA 01003, USA

Abstract

Versatile drug delivery devices using nanoporous membranes consisting of gold nanorods and dendrimers have been demonstrated to provide light-triggered on-demand pulsatile release from a reservoir containing highly enriched therapeutics for a real patient's needs. The drug release rate is directly correlated with the temperature increase and irradiated energy of a near-IR laser in both static and fluidic devices. This biocompatible platform for on-demand control was further confirmed by in vitro experiments. Interestingly, different responses to stimuli were obtained from each drug in the absence and presence of NIR light, indicating the versatile potential of our on-demand drug delivery system in less-invasive therapies requiring multi-drug delivery strategies. The enhanced delivery system will improve therapeutic efficacy and reduce side effects through regulation of plasma drug profiles.

Graphical abstract: Externally controlled drug release using a gold nanorod contained composite membrane

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Article information

DOI
https://doi.org/10.1039/C6NR00362A
Article type
Paper
Submitted
17 Jan 2016
Accepted
16 May 2016
First published
17 May 2016

Nanoscale, 2016,8, 11949-11955

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Externally controlled drug release using a gold nanorod contained composite membrane

K. Kim, M. Jo, S. Jeong, L. Palanikumar, V. M. Rotello, J. Ryu and M. Park, Nanoscale, 2016, 8, 11949 DOI: 10.1039/C6NR00362A

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