Issue 17, 2016
From the journal:

Green Chemistry

Selective synthesis of trisubstituted (trifluoromethyl)alkenes via ligand-free Cu-catalyzed syn hydroarylation, hydroalkenylation and hydroallylation of (trifluoromethyl)alkynes†

Y. Yamamoto,*a   E. Ohkuboa  and  M. Shibuyaa  

* Corresponding authors

a Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Chikusa, Nagoya 464-8601, Japan
E-mail: yamamoto-yoshi@ps.nagoya-u.ac.jp

Abstract

In the presence of catalytic amounts of Cu(OAc)2, the hydroarylation of (trifluoromethyl)alkynes with arylboronic acids proceeded in MeOH at 28 °C to afford diverse β-(trifluoromethyl)styrenes. Moreover, the hydroalkenylation and hydroallylation of a (trifluoromethyl)alkyne using styryl- and allylboronates afforded trifluoromethylated 1,3- and 1,4-dienes.

Graphical abstract: Selective synthesis of trisubstituted (trifluoromethyl)alkenes via ligand-free Cu-catalyzed syn hydroarylation, hydroalkenylation and hydroallylation of (trifluoromethyl)alkynes

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C6GC01782G
Article type
Communication
Submitted
30 Jun 2016
Accepted
17 Jul 2016
First published
19 Jul 2016

Green Chem., 2016,18, 4628-4632

Permissions

Request permissions

Selective synthesis of trisubstituted (trifluoromethyl)alkenes via ligand-free Cu-catalyzed syn hydroarylation, hydroalkenylation and hydroallylation of (trifluoromethyl)alkynes

Y. Yamamoto, E. Ohkubo and M. Shibuya, Green Chem., 2016, 18, 4628 DOI: 10.1039/C6GC01782G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements