Issue 31, 2016
From the journal:

Chemical Communications

Towards “bionic” proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics†

George M. Burslem,‡ab   Hannah F. Kyle,bc   Alexander L. Breeze,bcd   Thomas A. Edwards,bc   Adam Nelson,ab   Stuart L. Warrinerab  and  Andrew J. Wilson*ab  

* Corresponding authors

a School of Chemistry, University of Leeds, Woodhouse Lane, Leeds, UK

b Astbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds, UK
E-mail: a.j.wilson@leeds.ac.uk

c School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK

d Discovery Sciences, AstraZeneca R&D, Alderley Park, Cheshire, UK

Abstract

Using the HIF-1α transcription factor as a model, this manuscript illustrates how an extended sequence of α-amino acids in a polypeptide can be replaced with a non-natural topographical mimic of an α-helix comprised from an aromatic oligoamide. The resultant hybrid is capable of reproducing the molecular recognition profile of the p300 binding sequence of HIF-1α from which it is derived.

Graphical abstract: Towards “bionic” proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics

  • This article is part of the themed collection: Foldamers
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Article information

DOI
https://doi.org/10.1039/C6CC01812B
Article type
Communication
Submitted
29 Feb 2016
Accepted
11 Mar 2016
First published
24 Mar 2016
This article is Open Access
Creative Commons BY license

Chem. Commun., 2016,52, 5421-5424

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Towards “bionic” proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics

G. M. Burslem, H. F. Kyle, A. L. Breeze, T. A. Edwards, A. Nelson, S. L. Warriner and A. J. Wilson, Chem. Commun., 2016, 52, 5421 DOI: 10.1039/C6CC01812B

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