Issue 1, 2016
From the journal:

Organic & Biomolecular Chemistry

Accelerated cellular on- and off-target screening of bioactive compounds using microarrays†

Jiaqi Fu,a   Zhenkun Na,a   Bo Peng,a   Mahesh Uttamchandani*ab  and  Shao Q. Yao*a  

* Corresponding authors

a Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore
E-mail: chmyaosq@nus.edu.sg
Fax: +65 6770169
Tel: +65 65162925

b Defence Medical and Environmental Research Institute DSO National Laboratories, 27 Medical Drive, Singapore 117510, Singapore
E-mail: mahesh@nus.edu.sg

Abstract

In situ proteome labeling was carried out with 9 drug-like probes in live mammalian cells, with the corresponding cellular targets captured on microarrays and simultaneously screened using a diverse set of antibodies, revealing potential on- and off-targets.

Graphical abstract: Accelerated cellular on- and off-target screening of bioactive compounds using microarrays

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Article information

DOI
https://doi.org/10.1039/C5OB02233A
Article type
Communication
Submitted
29 Oct 2015
Accepted
16 Nov 2015
First published
16 Nov 2015

Org. Biomol. Chem., 2016,14, 59-64

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Accelerated cellular on- and off-target screening of bioactive compounds using microarrays

J. Fu, Z. Na, B. Peng, M. Uttamchandani and S. Q. Yao, Org. Biomol. Chem., 2016, 14, 59 DOI: 10.1039/C5OB02233A

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