Issue 10, 2016
From the journal:

Nanoscale

Nanoparticle-mediated photothermal effect enables a new method for quantitative biochemical analysis using a thermometer†

Guanglei Fu,a   Sharma T. Sanjay,a   Maowei Doua  and  XiuJun Li*abc  

* Corresponding authors

a Department of Chemistry, University of Texas at El Paso, 500 West University Ave, El Paso, Texas, USA
E-mail: xli4@utep.edu

b Biomedical Engineering, University of Texas at El Paso, 500 West University Ave, El Paso, Texas, USA

c Border Biomedical Research Center, University of Texas at El Paso, 500 West University Ave, El Paso, Texas, USA

Abstract

A new biomolecular quantitation method, nanoparticle-mediated photothermal bioassay, using a common thermometer as the signal reader was developed. Using an immunoassay as a proof of concept, iron oxide nanoparticles (NPs) captured in the sandwich-type assay system were transformed into a near-infrared (NIR) laser-driven photothermal agent, Prussian blue (PB) NPs, which acted as a photothermal probe to convert the assay signal into heat through the photothermal effect, thus allowing sensitive biomolecular quantitation using a thermometer. This is the first report of biomolecular quantitation using a thermometer and also serves as the first attempt to introduce the nanoparticle-mediated photothermal effect for bioassays.

Graphical abstract: Nanoparticle-mediated photothermal effect enables a new method for quantitative biochemical analysis using a thermometer

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Article information

DOI
https://doi.org/10.1039/C5NR09051B
Article type
Communication
Submitted
20 Dec 2015
Accepted
18 Jan 2016
First published
19 Jan 2016

Nanoscale, 2016,8, 5422-5427

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Nanoparticle-mediated photothermal effect enables a new method for quantitative biochemical analysis using a thermometer

G. Fu, S. T. Sanjay, M. Dou and X. Li, Nanoscale, 2016, 8, 5422 DOI: 10.1039/C5NR09051B

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