Issue 32, 2015
From the journal:

Chemical Communications

Complementary hydrogen bonding interaction triggered co-assembly of an amphiphilic peptide and an anti-tumor drug†

Hong Cheng,a   Yin-Jia Cheng,a   Sushant Bhasin,b   Jing-Yi Zhu,a   Xiao-Ding Xu,*a   Ren-Xi Zhuoa  and  Xian-Zheng Zhang*a  

* Corresponding authors

a Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China
E-mail: xd-xu@whu.edu.cn, xz-zhang@whu.edu.cn
Fax: +86-27-68754509
Tel: +86-27-68755993

b Nanotechnology Engineering Program, University of Waterloo, Waterloo N2L 3G1, Ontario, Canada

Abstract

We report a new tumor-targeting amphiphilic peptide that can form complementary hydrogen bonds with anti-tumor drug methotrexate (MTX), leading to reversible self-assembled morphology transition from loose micelles to densely packed nanorods or nanofibers. The MTX loaded nanorods can target tumor cells and show more than 2-fold higher cytotoxicity (IC50 = 0.38 mg L−1) than that towards normal cells (IC50 = 0.89 mg L−1).

Graphical abstract: Complementary hydrogen bonding interaction triggered co-assembly of an amphiphilic peptide and an anti-tumor drug

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C5CC00501A
Article type
Communication
Submitted
18 Jan 2015
Accepted
11 Mar 2015
First published
11 Mar 2015

Chem. Commun., 2015,51, 6936-6939

Author version available

Download author version (PDF)

Permissions

Request permissions

Complementary hydrogen bonding interaction triggered co-assembly of an amphiphilic peptide and an anti-tumor drug

H. Cheng, Y. Cheng, S. Bhasin, J. Zhu, X. Xu, R. Zhuo and X. Zhang, Chem. Commun., 2015, 51, 6936 DOI: 10.1039/C5CC00501A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements