Issue 9, 2015
From the journal:

Journal of Materials Chemistry B

Stimulation of wound healing by PU/hydrogel composites containing fibroblast growth factor-2

Yiu-Jiuan Lin,a   Ga-Hwa Lee,b   Chih-Wei Chou,c   Yi-Peng Chen,d   Te-Hsing Wue  and  Hong-Ru Lin*b  

* Corresponding authors

a Department of Nursing, Chung Hwa University of Medical Technology, Tainan 717, Taiwan

b Department of Chemical and Materials Engineering, Southern Taiwan University of Science and Technology, Tainan 710, Taiwan
E-mail: hrlin@mail.stust.edu.tw
Fax: +886-6-242-5741
Tel: +886-6-253-3131

c Department of Cosmeceutics, College of Pharmacy, China Medical University, Taichung 404, Taiwan

d Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan 710, Taiwan

e Institute of Nuclear Energy Research, Taoyuan 32546, Taiwan

Abstract

In this study, polyurethane (PU)/hydrogel composites were fabricated for wound healing applications. The hydrogel is a copolymer of thermosensitive N-isopropyl acrylamide (NIPAAm) and acrylic acid (AAc). γ-ray irradiation was employed to simultaneously copolymerize NIPAAm with AAc and graft the hydrogel onto porous PU. Fibroblast growth factor-2 (FGF-2) was incorporated into the composite to facilitate wound healing. The physical properties of the composites were characterized, the in vitro release of FGF-2 was examined, and in vivo tests were conducted. The results indicate that the thermosensitive hydrogel can absorb most of the wound exudates due to its high water uptake ability. Due to its thermosensitive properties, the PU/hydrogel composite is easier to strip off than that of commercial wound dressing, which prevents additional injury to the wound when replacing the wound dressing. In vivo results show that the PU/hydrogel composite incorporating FGF-2 could accelerate wound healing and reduce scar formation.

Graphical abstract: Stimulation of wound healing by PU/hydrogel composites containing fibroblast growth factor-2

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Article information

DOI
https://doi.org/10.1039/C4TB01638F
Article type
Paper
Submitted
03 Oct 2014
Accepted
22 Jan 2015
First published
23 Jan 2015

J. Mater. Chem. B, 2015,3, 1931-1941

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Stimulation of wound healing by PU/hydrogel composites containing fibroblast growth factor-2

Y. Lin, G. Lee, C. Chou, Y. Chen, T. Wu and H. Lin, J. Mater. Chem. B, 2015, 3, 1931 DOI: 10.1039/C4TB01638F

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