Gold nanoparticle-decorated MoS2 nanosheets for simultaneous detection of ascorbic acid, dopamine and uric acid

Haofan Sun; Jie Chao; Xiaolei Zuo; Shao Su; Xingfen Liu; Lihui Yuwen; Chunhai Fan; Lianhui Wang

doi:10.1039/C4RA04046E

Gold nanoparticle-decorated MoS₂ nanosheets for simultaneous detection of ascorbic acid, dopamine and uric acid†

Haofan Sun,‡^a Jie Chao,‡^b Xiaolei Zuo,^b Shao Su,*^a Xingfen Liu,^a Lihui Yuwen,^a Chunhai Fan^ab and Lianhui Wang*^a

* Corresponding authors

^a Key Laboratory for Organic Electronics & Information Displays (KLOEID), Institute of Advanced Materials (IAM), School of Materials Science and Engineering, Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing, China
E-mail: iamssu@njupt.edu.cn, iamlhwang@njupt.edu.cn
Tel: +86 25 85866333

^b Division of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China

Abstract

An electrochemical sensor has been developed for simultaneous detection of dopamine (DA), uric acid (UA) and ascorbic acid (AA) based on a gold nanoparticle-decorated MoS₂ nanocomposite (AuNPs@MoS₂) modified electrode. The AuNPs@MoS₂ nanocomposite has been synthesized by electrodeposition of AuNPs on the MoS₂ nanosheets, which possesses better properties than pure AuNPs and MoS₂. The AuNPs@MoS₂ film modified electrode showed excellent electrocatalytic activity toward the oxidation of AA, DA and UA with three well-resolved oxidation peaks. The peak separation of AA–DA, DA–UA and AA–UA is 151 mV, 137 mV and 288 mV, respectively, which permits the modified electrode to individually or simultaneously analyze AA, DA and UA by differential pulse voltammetry (DPV). Under optimum conditions, the AuNPs@MoS₂ modified electrode exhibits linear response toward AA, DA and UA in the range of 50–100 000 μM, 0.05–30 μM and 50–40 000 μM, respectively. Moreover, the MoS₂-based modified electrode was successfully employed to determine DA in human serum samples with satisfactory results.

This article is part of the themed collection: Sensors for health and happiness

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Article information

DOI: https://doi.org/10.1039/C4RA04046E
Article type: Paper
Submitted: 03 May 2014
Accepted: 13 Jun 2014
First published: 13 Jun 2014

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RSC Adv., 2014,4, 27625-27629

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Gold nanoparticle-decorated MoS₂ nanosheets for simultaneous detection of ascorbic acid, dopamine and uric acid

H. Sun, J. Chao, X. Zuo, S. Su, X. Liu, L. Yuwen, C. Fan and L. Wang, RSC Adv., 2014, 4, 27625 DOI: 10.1039/C4RA04046E

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