Issue 45, 2014
From the journal:

RSC Advances

Intra-arterial infusion of PEGylated upconversion nanophosphors to improve the initial uptake by tumors in vivo†

Xingjun Zhu,‡a   Brandon Da Silva,‡b   Xianmei Zou,a   Bin Shen,a   Yun Sun,a   Wei Fenga  and  Fuyou Li*a  

* Corresponding authors

a Department of Chemistry & Institute of Biomedicine Science & State Key Laboratory of Molecular Engineering of Polymers, Fudan University, 220 Handan Road, Shanghai 200433, P.R. China
E-mail: fyli@fudan.edu.cn

b Department of Chemistry, Georgetown University, 3700 O Street N.W., Washington D.C. 20057, USA

Abstract

An alternative method to the intravenous administration of upconversion nanoparticles (UCNPs) was highlighted by the use of an unconventional blood pathway, the artery. The uptake of NaYF4:Yb,Tm@SiO2 nanoparticles modified with polyethylene glycol (PEG-UCNPs) by MCF-7 tumors following intra-arterial (i.a.) injection was nearly three-fold higher than that obtained with intravenous (i.v.) injection. This result suggests a new method for administering UCNPs in vivo to achieve more efficient tumor targeting and therapy.

Graphical abstract: Intra-arterial infusion of PEGylated upconversion nanophosphors to improve the initial uptake by tumors in vivo

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C4RA01815J
Article type
Communication
Submitted
01 Mar 2014
Accepted
02 May 2014
First published
08 May 2014

RSC Adv., 2014,4, 23580-23584

Permissions

Request permissions

Intra-arterial infusion of PEGylated upconversion nanophosphors to improve the initial uptake by tumors in vivo

X. Zhu, B. Da Silva, X. Zou, B. Shen, Y. Sun, W. Feng and F. Li, RSC Adv., 2014, 4, 23580 DOI: 10.1039/C4RA01815J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements