Issue 13, 2015
From the journal:

RSC Advances

Structural lipid nanoparticles self-assembled from electrospun core–shell polymeric nanocomposites†

Deng-Guang Yu,*a   Kenneth White,b   Nicholas Chatterton,b   Ying Li,a   Lingling Lia  and  Xia Wang*a  

* Corresponding authors

a School of Materials Science & Engineering, University of Shanghai for Science and Technology, Shanghai 200093, P.R. China
E-mail: ydg017@usst.edu.cn, wangxia@usst.edu.cn

b School of Human Sciences, Faculty of Life Sciences and Computing, London Metropolitan University, 166-220 Holloway Road, London N7 8DB, UK

Abstract

Electrospun polymeric core–shell nanocomposites are exploited as templates to manipulate molecular self-assembly for preparing structural lipid nanoparticles, during which the confinement effect of fibers together with their core–shell structure, the aqueous environment and the secondary interactions, all contributed synergistically to facilitate molecular self-aggregation to produce lipid nanoparticles with a drug entrapment efficiency of 95.9% with a sustained drug release profile.

Graphical abstract: Structural lipid nanoparticles self-assembled from electrospun core–shell polymeric nanocomposites

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C4RA14001J
Article type
Communication
Submitted
06 Nov 2014
Accepted
22 Dec 2014
First published
23 Dec 2014

RSC Adv., 2015,5, 9462-9466

Author version available

Download author version (PDF)

Permissions

Request permissions

Structural lipid nanoparticles self-assembled from electrospun core–shell polymeric nanocomposites

D. Yu, K. White, N. Chatterton, Y. Li, L. Li and X. Wang, RSC Adv., 2015, 5, 9462 DOI: 10.1039/C4RA14001J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements