Issue 99, 2014
From the journal:

RSC Advances

A convenient palladium-catalyzed carbonylative synthesis of quinazolines from 2-aminobenzylamine and aryl bromides†

Jianbin Chen,‡a   Kishore Natte,‡a   Helfried Neumanna  and  Xiao-Feng Wu*a  

* Corresponding authors

a Leibniz-Institut für Katalyse an der Universität Rostock, Albert-Einstein-Straße 29a, 18059 Rostock, Germany
E-mail: xiao-feng.wu@catalysis.de

Abstract

A novel and practical strategy towards quinazoline scaffolds synthesis has been achieved. Through palladium-catalyzed carbonylative coupling of 2-aminobenzylamine with aryl bromides, the desired quinazolines were produced in moderate to good yields for the first time. The reactions followed an aminocarbonylation–condensation–oxidation sequence in a one-pot one-step manner. Preliminary investigation showed DMSO serves both as solvent and oxidant in this procedure.

Graphical abstract: A convenient palladium-catalyzed carbonylative synthesis of quinazolines from 2-aminobenzylamine and aryl bromides

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Article information

DOI
https://doi.org/10.1039/C4RA11303A
Article type
Communication
Submitted
26 Sep 2014
Accepted
24 Oct 2014
First published
24 Oct 2014

RSC Adv., 2014,4, 56502-56505

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A convenient palladium-catalyzed carbonylative synthesis of quinazolines from 2-aminobenzylamine and aryl bromides

J. Chen, K. Natte, H. Neumann and X. Wu, RSC Adv., 2014, 4, 56502 DOI: 10.1039/C4RA11303A

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