Issue 68, 2014

Efficient synthesis of 5-hydroxymethyl-, 5-formyl-, and 5-carboxyl-2′-deoxycytidine and their triphosphates

Abstract

An efficient P(V)-N activation strategy for the preparation of high-quality 5-hydroxymethyl-, 5-formyl-, and 5-carboxyl-2′-deoxycytidine triphosphates has been developed. The method was also optimized for gram-scale synthesis of the corresponding parent nucleosides from 2′-deoxythymidine.

Graphical abstract: Efficient synthesis of 5-hydroxymethyl-, 5-formyl-, and 5-carboxyl-2′-deoxycytidine and their triphosphates

Supplementary files

Article information

Article type
Communication
Submitted
06 Jun 2014
Accepted
06 Aug 2014
First published
06 Aug 2014

RSC Adv., 2014,4, 36036-36039

Author version available

Efficient synthesis of 5-hydroxymethyl-, 5-formyl-, and 5-carboxyl-2′-deoxycytidine and their triphosphates

Q. Sun, J. Sun, S. Gong, C. Wang, S. Pu and F. Feng, RSC Adv., 2014, 4, 36036 DOI: 10.1039/C4RA07670B

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