SCHEDULED MAINTENANCE
A highly selective turn-on fluorescent sensor for fluoride and its application in imaging of living cells†
Abstract
A fluorescent probe (FS) based on a fluoride-specific desilylation reaction has been developed for a highly selective and sensitive detection of F−. In the presence of F−, the probe FS provided significant green fluorescence enhancement, while other anions produced only minor changes in fluorescence intensity. The probe FS has a limit of detection of 1.45 μM, which is reasonable for the detection of micromolar concentrations of F− ions. The maximum fluorescence enhancement induced by F− in the probe was observed over the pH range 7–10. Moreover, fluorescence microscopy imaging using mouse leukaemic monocyte macrophage showed that the probe FS could be an efficient fluorescent probe for F− ions in living cells.
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