Issue 3, 2015
From the journal:

Chemical Communications

MMP-2 responsive polymeric micelles for cancer-targeted intracellular drug delivery†

Wei-Hai Chen,a   Guo-Feng Luo,a   Qi Lei,a   Hui-Zhen Jia,a   Sheng Hong,a   Qing-Rong Wang,*a   Ren-Xi Zhuoa  and  Xian-Zheng Zhang*a  

* Corresponding authors

a Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China
E-mail: wangqr@whu.edu.cn, xz-zhang@whu.edu.cn
Fax: +86 27 6875 4509
Tel: +86 27 6875 5993

Abstract

Multifunctional Biotin-PEG-b-PLL(Mal)-peptide-DOX polymeric micelles were prepared to selectively eliminate cancer cells. The micelles were able to enhance cancer cell uptake via the receptor-mediated endocytosis and respond to the stimulus of cancer cell excessive secreted protease MMP-2 to release the anticancer drug and induce apoptosis of cancer cells in a targeted manner.

Graphical abstract: MMP-2 responsive polymeric micelles for cancer-targeted intracellular drug delivery

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Article information

DOI
https://doi.org/10.1039/C4CC07563C
Article type
Communication
Submitted
25 Sep 2014
Accepted
07 Oct 2014
First published
07 Oct 2014

Chem. Commun., 2015,51, 465-468

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MMP-2 responsive polymeric micelles for cancer-targeted intracellular drug delivery

W. Chen, G. Luo, Q. Lei, H. Jia, S. Hong, Q. Wang, R. Zhuo and X. Zhang, Chem. Commun., 2015, 51, 465 DOI: 10.1039/C4CC07563C

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